This HowTo explains wordpress setup with nginx on CentOS:

Install the required packages

yum install php nginx php-fpm mysql-server php-mysql

Create Nginx VHOST

vi /etc/nginx/conf.d/wordpress.conf

server {
listen       80;
location / {
root   /var/www/html;
index  index.html index.htm index.php;

location ~ \.php$ {
root           html;
fastcgi_index  index.php;
fastcgi_param  SCRIPT_FILENAME  /var/www/html$fastcgi_script_name;
include        fastcgi_params;


Download and Extract wordpress

cd /var/www/html
tar zxf latest.tar.gz
mv * wordpress/* ../
chown -R apache:apache /var/www/html/

Login to mysql and create database

mysql-u root -p
create database wordpress;

Create a host entry and browse the page to proceed with the installation wizard